The role of vaccines in COVID-19 control strategies in Singapore and China.

Objectives: In this article, we critically review the development and implementation of COVID-19 vaccination in Singapore and China during the pandemic. Methods: We collect and analyze data from a range of sources, including scholarly articles, statistics and documents from national governments in the two countries, and reports from international organizations. Results: There are important differences in the two countries' approaches to the evolving pandemic, and thus the roles that COVID-19 vaccination plays in the overall response strategies in these two countries. Conclusions: Whereas Singapore adopted a "living with the virus" strategy, China continued to pursue a COVID-zero strategy. The overall COVID-19 response strategy of Singapore was largely shared by many countries in the world, while that of China was more unique and hardly imitated elsewhere. Nevertheless, vaccination played a significant role in both countries' responses to the pandemic. A comparison and contrast between the vaccination processes in these two countries thus shed important light on the drivers and outcomes of COVID-19 vaccination in different settings.

Long-term Effects of the COVID-19 Pandemic on Public Sentiments in Mainland China: Sentiment Analysis of Social Media Posts.

BACKGROUND: The COVID-19 outbreak has induced negative emotions among people. These emotions are expressed by the public on social media and are rapidly spread across the internet, which could cause high levels of panic among the public. Understanding the changes in public sentiment on social media during the pandemic can provide valuable information for developing appropriate policies to reduce the negative impact of the pandemic on the public. Previous studies have consistently shown that the COVID-19 outbreak has had a devastating negative impact on public sentiment. However, it remains unclear whether there has been a variation in the public sentiment during the recovery phase of the pandemic. OBJECTIVE: In this study, we aim to determine the impact of the COVID-19 pandemic in mainland China by continuously tracking public sentiment on social media throughout 2020. METHODS: We collected 64,723,242 posts from Sina Weibo, China's largest social media platform, and conducted a sentiment analysis based on natural language processing to analyze the emotions reflected in these posts. RESULTS: We found that the COVID-19 pandemic not only affected public sentiment on social media during the initial outbreak but also induced long-term negative effects even in the recovery period. These long-term negative effects were no longer correlated with the number of new confirmed COVID-19 cases both locally and nationwide during the recovery period, and they were not attributed to the postpandemic economic recession. CONCLUSIONS: The COVID-19 pandemic induced long-term negative effects on public sentiment in mainland China even as the country recovered from the pandemic. Our study findings remind public health and government administrators of the need to pay attention to public mental health even once the pandemic has concluded.

The New Liability of Origin in Global Decoupling

[...]the mechanisms that give rise to the new LOR are more formal, explicit, and coercive. A series of events have underpinned this process, including the introduction of new foreign interference laws in Australia, the Australian government's banning of Huawei from 5G mobile infrastructure, and Australia's push for a global inquiry into the origins of COVID-19. Since 2020, China has introduced various restrictions on Australian goods imports, such as coal, lobsters, timber, red meat, wine, and barley. According to independent national surveys,[3] Australians’ trust that China will act responsibly has declined from 52% in 2018 to 23% in 2020. [...]the occurrences of the words China, Chinese, or Sino in annual reports of 26 companies decreased from 2017–2020 compared with 2013–2016 (17 companies increased their use of these terms).

Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review.

Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, including those for Middle East respiratory syndrome-Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS)-CoV, to guide policymakers globally on their prioritization of resources for research and development. A systematic search was carried out in three major electronic databases (PubMed, Embase and Cochrane Library) to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Supplementary strategies through Google Search and personal communications were used. A total of 27 studies fulfilled the criteria for review. Several laboratory protocols for confirmation of suspected 2019-nCoV cases using real-time reverse transcription polymerase chain reaction (RT-PCR) have been published. A commercial RT-PCR kit developed by the Beijing Genomic Institute is currently widely used in China and likely in Asia. However, serological assays as well as point-of-care testing kits have not been developed but are likely in the near future. Several vaccine candidates are in the pipeline. The likely earliest Phase 1 vaccine trial is a synthetic DNA-based candidate. A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. However, there are currently no effective specific antivirals or drug combinations supported by high-level evidence.